Format

Send to

Choose Destination
Clin J Sport Med. 2012 Nov;22(6):488-94. doi: 10.1097/JSM.0b013e3182580ce8.

Hyponatremia is associated with higher NT-proBNP than normonatremia after prolonged exercise.

Author information

1
MP Sports Physicians, Victoria, Australia. drgaharris@yahoo.com

Abstract

OBJECTIVE:

To determine the incidence of and risk factors for exercise-associated hyponatremia (EAH) in cyclists completing a long-distance bike ride and to assess whether postexercise serum NT-proBNP concentration (brain natriuretic protein precursor) differed between riders with and without EAH.

DESIGN:

Observational study.

SETTING:

"Around the Bay in a Day" cycle event, October 2010.

PARTICIPANTS:

One hundred thirty-nine cyclists prospectively enrolled, with 90 completing 210 or 250 km.

MAIN OUTCOME MEASURES:

Body weight change and fluid intake during the event, and postevent serum sodium concentration ([Na+]) and NT-proBNP concentration ([NT-proBNP]).

RESULTS:

Four riders (4.5%) were hyponatremic ([Na+] < 135 mmol/L). The lowest postride [Na+] was 126 mmol/L. Hyponatremia was associated with a mean weight gain of 3.4 kg (3.9% of total body weight). Significant negative correlations were found between postride [Na+] and change in weight (r = -0.34; P < 0.01) and fluid intake when expressed as total volume (r = -0.35; P < 0.01), mL/kg body weight (r = 0.33; P < 0.01), mL·kg·h (r = -0.27; P < 0.01), or mL/h (r = -0.29; P < 0.01). NT-proBNP concentrations levels in 3 of the 4 hyponatremic subjects were markedly elevated compared with eunatremic subjects matched for age, sex, distance ridden, training, and medical history.

CONCLUSIONS:

Exercise-associated hyponatremia was found to occur in 4.5% of the study group and was associated with weight gain during a prolonged bike ride. Postride [Na+] varied inversely with weight change and with fluid intake. Three of 4 hyponatremic riders had significant elevations of [NT-proBNP]. These results support the hypothesis that overconsumption of hypotonic fluids in this setting is the most important cause of EAH.

PMID:
22584963
DOI:
10.1097/JSM.0b013e3182580ce8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center