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Antiviral Res. 2012 Jul;95(1):30-6. doi: 10.1016/j.antiviral.2012.05.001. Epub 2012 May 11.

Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation.

Author information

1
Nanjing University School of Medicine and Jiangsu Laboratory of Molecular Medicine, Nanjing Jiangsu 210093, China.

Abstract

Stilbenoids including resveratrol contain the basic structural unit of 1,2-diphenylethylene. Naturally occurring stilbenoids have broad structural features due to oligomerization and modifications and some have demonstrated potent biological activities. In an effort to identify bioactive stilbenoids, we screened a group of dimeric and oligomeric stilbenoids against HSV-1 and HSV-2 infection. Several trimeric and tetrameric derivatives showed anti-herpetic activity at single digit micromolar concentrations. HSV-1 and HSV-2 replication requires for NF-κB and MAPK activation. The compounds showed no inhibitory activity against NF-κB and Erk/MAPK activation, instead those compounds promoted rapid and transient release of reactive oxygen species (ROS). Addition of N-acetylcysteine (NAC), a scavenger of ROS, reversed the inhibitory effect of those compounds against HSV replication. In addition to the identification of resveratrol derivatives with potent anti-HSV activity, our results uncover a mechanism of polyphenol-mediated anti-HSV response, linking anti-herpetic activity of oligomeric stilbenoids to innate immunity.

PMID:
22584350
DOI:
10.1016/j.antiviral.2012.05.001
[Indexed for MEDLINE]

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