Format

Send to

Choose Destination
Diabetes Care. 2012 Jul;35(7):1446-54. doi: 10.2337/dc11-1928. Epub 2012 May 14.

Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.

Collaborators (249)

Mathieu C, Vercammen C, Blumer I, Bowering K, Clayton DB, Conway J, Gottesman I, Harris S, Woo V, Allesis C, Angeletti S, Avignon A, Ayon F, Benichou M, Boitard C, Catargi B, Charpentier G, Clavel S, Courreges JP, Debussche X, Delemer B, Fontaine P, Ghanassia E, Gouet D, Haddad E, Hadjadj S, Hassler P, Hochner I, Le Moullec N, Lecomte P, Mira R, Moulin P, Reynaud D, Vexiau P, Barakat A, Behnke T, Burchert D, Daikeler R, Dietlein M, Drynda K, Fach EM, Goelz S, Hamann A, Hammer H, Hanefeld M, Hinz A, Jordan R, Kaiser M, Klinge A, Kohn W, Lundershausen R, Maxeiner S, Merfort F, Milek K, Mölle A, Paschen B, Pohl A, Rose L, Sauter J, Schlecht K, Schramm C, Schumm-Draeger PM, Schwinn J, Segner A, Seufert J, Siegel E, Simon J, Steindorf J, Stübler P, Tosch-Sisting R, Vidal S, Weber M, Wenzl-Bauer V, Wilhelm K, Arcangeli A, Baroni MG, Boemi M, Bonomo M, Bossi A, Buscemi S, Caputo S, Ciavarella A, Corsi L, Dal Moro E, D'Amico E, Di Bartolo P, Fatati G, Gambardella S, Morviducci L, Orsi E, Paleari F, Parillo M, Pipicelli G, Puccio L, Pupillo M, Sforza A, Tomasi F, Venezia A, Vespasiani G, Zavaroni D, Agous I, Arntzenius AB, Bianchi R, Brouwer CB, De Valk HW, DeVries JH, Feis WL, Hentenaar GA, Hoogenberg K, Jebbink MC, Kok S, Kooy A, Lokhorst B, Mevissen HG, Oldenburg-Ligtenberg PC, Schweitzer D, Van de Walle VE, van Doesburg GJ, Verhage AH, Willink MG, Albero Gamboa R, Ampudia-Blasco FJ, Anglada Barcelo J, Brito Sanfiel M, Cañizo F, Domínguez R, Dominguez Escribano J, Escalada J, Faure Nogueras E, Gómez Cerezo J, González Sarmiento E, Izaguirre J, Jodar E, Llorente Gómez De Segura I, López Tinoco C, Lucas A, Merchante Alfaro A, Mezquita Raya P, Morales Pérez F, Muros de Fuentes T, Paja Fano M, Paniagua González JA, Pujol De La Llave E, Ramírez Muñoz L, Ricart W, Rovira A, Sánchez Rodríguez A, Varela Aguilar JM, Abraham P, Andrews J, Atkin S, Bain S, Davies M, Dayan C, Gibson M, Harper R, Hitman G, Hunter S, Jude E, Kilvert A, Kumar S, Lindsay J, Mackie A, MacRury S, Matthews D, Mcknight J, Narendran P, O'Hare J, Ramtoola S, Robinson A, Rooney D, Russell-Jones D, Saravanan P, Stephens WP, Tan G, Vaidya B, Vora J, Whitelaw D, Wilding J, Wiles P, Winocour P, Abreu F, Acampora M, Ahmed A, Bays H, Bergenstal R, Brusco O, Chaykin L, Cherlin R, Chilka S, Christina M, Chuck L, Cohen J, Comulada-Rivera A, Corder C, D'Alessio D, Dunn L, Dwarakanathan A, Feinglos M, Forbes R, Gilbert J, Greco S, Griffing G, Harris M, Harris R, Harris S, Hershon K, Hoekstra J, Hollander P, Hone J, Huffman D, Jain R, Kapoor A, Kayne D, Kennedy J, Levin P, Lipetz R, Lubin B, McCartney M, Meneghini L, Murillo A, Ovalle F, Perez E, Phillips L, Popov D, Ramos-Roman M, Ratcliff L, Ratner R, Reed J, Rodbard HW, Rosenstock J, Sachson R, Saponaro J, Scott C, Selam JL, Stoever J, Sulman S, Testa J, Philis-Tsimikas A, Unger J, Vigersky R, Weissman P, Wheeler K, Wittmer B, Yeoman G, Zamora B, Zieve F, Zimmerman T, Zonszein J.

Author information

1
Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.

Abstract

OBJECTIVE:

We evaluated the addition of liraglutide to metformin in type 2 diabetes followed by intensification with basal insulin (detemir) if glycated hemoglobin (A1C) ≥7%.

RESEARCH DESIGN AND METHODS:

In 988 participants from North America and Europe uncontrolled on metformin ± sulfonylurea, sulfonylurea was discontinued and liraglutide 1.8 mg/day added for 12 weeks (run-in). Subsequently, those with A1C ≥7% were randomized 1:1 to 26 weeks' open-label addition of insulin detemir to metformin + liraglutide (n = 162) or continuation without insulin detemir (n = 161). Patients achieving A1C <7% continued unchanged treatment (observational arm). The primary end point was A1C change between randomized groups.

RESULTS:

Of 821 participants completing the run-in, 61% (n = 498) achieved A1C <7% (mean change -1.3% from 7.7% at start), whereas 39% (n = 323) did not (-0.6% from 8.3% at start). During run-in, 167 of 988 (17%) withdrew; 46% of these due to gastrointestinal adverse events. At week 26, A1C decreased further, by 0.5% (from 7.6% at randomization) with insulin detemir (n = 162) versus 0.02% increase without insulin detemir (n = 157) to 7.1 and 7.5%, respectively (estimated treatment difference -0.52 [95% CI -0.68 to -0.36]; P < 0.0001). Forty-three percent of participants with insulin detemir versus 17% without reached A1C <7%. Mean weight decreased by 3.5 kg during run-in, then by 0.16 kg with insulin detemir or 0.95 kg without insulin detemir. In the randomized phase, no major hypoglycemia occurred and minor hypoglycemia rates were 0.286 and 0.029 events per participant-year with and without insulin detemir (9.2 vs. 1.3%).

CONCLUSIONS:

Supplementation of metformin with liraglutide and then insulin detemir was well tolerated in the majority of patients, with good glycemic control, sustained weight loss, and very low hypoglycemia rates.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00856986.

PMID:
22584132
PMCID:
PMC3379583
DOI:
10.2337/dc11-1928
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center