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Virol J. 2012 May 14;9:92. doi: 10.1186/1743-422X-9-92.

HHV-8 reduces dendritic cell migration through down-regulation of cell-surface CCR6 and CCR7 and cytoskeleton reorganization.

Author information

1
Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Experimental Medicine, La Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy. Mara.cirone@uniroma1.it

Abstract

BACKGROUND:

For an efficient immune response against viral infection, dendritic cells (DCs) must express a coordinate repertoire of receptors that allow their recruitment to the sites of inflammation and subsequently to the secondary lymphoid organs in response to chemokine gradients.Several pathogens are able to subvert the chemokine receptor expression and alter the migration properties of DCs as strategy to escape from the immune control.

FINDINGS:

Here we report the inhibitory effect of Human Herpesvirus 8 (HHV-8) on the migratory behavior of immature and mature DCs. We found that the virus altered the DC chemokine receptor expression and chemokine induced migration. Moreover HHV-8 was also able to interfere with basal motility of DCs by inducing cytoskeleton modifications.

CONCLUSION:

Based on our findings, we suggest that HHV-8 is able to subvert the DC migration capacity and this represents an additional mechanism which interferes with their immune-functions.

PMID:
22583958
PMCID:
PMC3442995
DOI:
10.1186/1743-422X-9-92
[Indexed for MEDLINE]
Free PMC Article
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