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Mol Brain. 2012 May 14;5:14. doi: 10.1186/1756-6606-5-14.

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB.

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1
Department of Neuroscience, Columbia University, New York, NY 10032, USA. erk5@columbia.edu

Abstract

The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biology of memory storage possible, and then detail the discovery and early history of these six molecular steps and their roles in explicit memory.

PMID:
22583753
PMCID:
PMC3514210
DOI:
10.1186/1756-6606-5-14
[Indexed for MEDLINE]
Free PMC Article
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