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Med Hypotheses. 2012 Aug;79(2):189-92. doi: 10.1016/j.mehy.2012.04.031. Epub 2012 May 12.

How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects.

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1
Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA. frassett@gcrc.ucsf.edu

Abstract

Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects.

PMID:
22583559
DOI:
10.1016/j.mehy.2012.04.031
[Indexed for MEDLINE]
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