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Hypertens Pregnancy. 2012;31(2):278-91. doi: 10.3109/10641955.2011.640375.

A mass spectrometric multicenter study supports classification of preeclampsia as heterogeneous disorder.

Author information

1
Department of Obstetrics and Gynecology, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Abstract

OBJECTIVE:

The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting.

METHODS:

Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four centers were prospectively analyzed with predefined rule sets.

RESULTS:

Overall sample classification reached sensitivity of 0.88 and specificity of 0.73. Separate calculations for early-onset PEs only (before 34 weeks of gestation) revealed sensitivity of 0.88 and specificity of 0.89.

CONCLUSION:

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry serum-profiling with center-wise standardization offers a fast and robust method to classify PE and contributes to the theory of PE being a heterogeneous disorder that ought to be subclassified.

PMID:
22582870
DOI:
10.3109/10641955.2011.640375
[Indexed for MEDLINE]

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