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Front Immunol. 2012 May 9;3:115. doi: 10.3389/fimmu.2012.00115. eCollection 2012.

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.

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1
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid Madrid, Spain.

Abstract

Increasing evidence favors the notion that, before triggering, the T cell antigen receptor (TCR) forms nanometer-scale oligomers that are called nanoclusters. The organization of the TCR in pre-existing oligomers cannot be ignored when analyzing the properties of ligand (pMHC) recognition and signal transduction. As with other membrane receptors, the existence of TCR oligomers points out to cooperativity phenomena. We review the data in support of conformational changes in the TCR as the basic principle to transduce the activation signal to the cytoplasm and the incipient data suggesting cooperativity within nanoclusters.

KEYWORDS:

TCR; conformational changes; nanoclusters; oligomers

PMID:
22582078
PMCID:
PMC3348506
DOI:
10.3389/fimmu.2012.00115
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