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Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Mar;156(1):1-6. doi: 10.5507/bp.2012.003.

BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas.

Author information

1
School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom. k.vrzalikova@bham.ac.uk

Abstract

AIMS:

The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas.

METHODS AND RESULTS:

This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas.

CONCLUSIONS:

BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

PMID:
22580854
DOI:
10.5507/bp.2012.003
[Indexed for MEDLINE]
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