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Bioorg Med Chem. 2012 Jun 15;20(12):3837-42. doi: 10.1016/j.bmc.2012.04.029. Epub 2012 Apr 21.

Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels.

Author information

1
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan.

Abstract

Sodium dl-α-tocopheryl-6-O-phosphate (1), a water-soluble derivative of vitamin E (dl-α-tocopherol, 2), exhibits protective effects against various type of skin damage. As reported herein, we found that topical application of 1 improves hygroscopicity and water holding capacity in the stratum corneum of hairless mice in vivo by increasing the ceramide content. In normal human epidermal keratinocytes, treatment with 1 increases ceramide levels and enhances gene expression of serine palmitoyltransferase, which catalyzes the first step of ceramide synthesis in vitro. In addition, 1 increases gene expressions of differentiation markers (transglutaminase 1, cytokeratin 10, involucrin and loricrin), and intracellular Ca(2+) concentrations. These results suggest that 1 could be an excellent agent for improving skin moisture-retention by enhancing ceramide synthesis through the induction of differentiation.

PMID:
22579618
DOI:
10.1016/j.bmc.2012.04.029
[Indexed for MEDLINE]

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