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Complement Ther Med. 2012 Aug;20(4):222-7. doi: 10.1016/j.ctim.2012.03.001. Epub 2012 Apr 8.

An investigation of the possible interaction between the use of Vitamin C and highly active antiretroviral therapy (HAART) adherence and effectiveness in treated HIV+ women.

Author information

1
Department of Family Medicine, Georgetown University Medical Center, Washington, DC 20007, United States. djm23@georgetown.edu

Abstract

OBJECTIVES:

Our goal in this study was to examine how Vitamin C interacts with antiretroviral therapy in individuals with HIV. We specifically evaluated how Vitamin C impacts highly active antiretroviral therapy (HAART) adherence and HAART effectiveness as adjudicated by HIV viral loads and CD4 cell counts. Women served as their own controls, comparing periods of Vitamin C usage with periods of non-usage.

DESIGN:

An intra-individual, cross-sectional comparative study 'nested' in the WIHS observational cohort study.

SUBJECTS:

Women in the Women's Interagency HIV Study (WIHS).

OUTCOME MEASURES:

Adherence, CD4 count and viral load.

RESULTS:

Our study population was drawn from 2813 HIV+ participants who contributed 44,588 visits in WIHS from October, 1994 to April, 2009. Among them, there were 1122 Vitamin C users with 4954 total visits where use was reported. In the multivariate model adjusting for age, education, race, income, drug use, Vitamin C use order and depression score, there was a 44% increase in the odds of ≥ 95% HAART adherence among participants during their period of Vitamin C use compared to when they were not using Vitamin C (OR=1.44; 95% CI=1.1-1.9; P-value=0.0179). There was an association with Vitamin C usage and CD4 counts on viral loads.

CONCLUSION:

Vitamin C usage appears to be associated with improved adherence. Future Vitamin C studies should target specific HAART drugs, and prospective clinical outcomes.

PMID:
22579434
PMCID:
PMC3351689
DOI:
10.1016/j.ctim.2012.03.001
[Indexed for MEDLINE]
Free PMC Article

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