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Cell. 2012 May 11;149(4):731-3. doi: 10.1016/j.cell.2012.04.014.

Network medicine strikes a blow against breast cancer.

Author information

1
Biotech Research and Innovation Center, University of Copenhagen, Denmark. janine.erler@bric.ku.dk

Abstract

Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

PMID:
22579276
DOI:
10.1016/j.cell.2012.04.014
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