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J Magn Reson. 2012 May;218:35-43. doi: 10.1016/j.jmr.2012.03.010. Epub 2012 Mar 24.

A new automatic baseline correction method based on iterative method.

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1
Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.

Abstract

A new automatic baseline correction method for Nuclear Magnetic Resonance (NMR) spectra is presented. It is based on an improved baseline recognition method and a new iterative baseline modeling method. The presented baseline recognition method takes advantages of three baseline recognition algorithms in order to recognize all signals in spectra. While in the iterative baseline modeling method, besides the well-recognized baseline points in signal-free regions, the 'quasi-baseline points' in the signal-crowded regions are also identified and then utilized to improve robustness by preventing the negative regions. The experimental results on both simulated data and real metabolomics spectra with over-crowded peaks show the efficiency of this automatic method.

PMID:
22578553
DOI:
10.1016/j.jmr.2012.03.010

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