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Neuron. 2012 May 10;74(3):440-51. doi: 10.1016/j.neuron.2012.04.015.

Harnessing the power of the endosome to regulate neural development.

Author information

1
Department of Neuroscience, University of Virginia, 409 Lane Road, Charlottesville, VA 22908, USA.

Abstract

Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond regulating entry of essential nutrients. In this review, we discuss the cell biological principles of endosomal trafficking, the neuronal adaptations to endosomal organization, and the role of endosomal trafficking in neural development. In particular, we consider how cell fate decisions, polarity, migration, and axon outgrowth and guidance are influenced by five endosomal tricks: dynamic modulation of receptor levels by endocytosis and recycling, cargo-specific responses via cargo-specific endocytic regulators, cell-type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regulation of ligand processing and trafficking.

PMID:
22578496
PMCID:
PMC3351757
DOI:
10.1016/j.neuron.2012.04.015
[Indexed for MEDLINE]
Free PMC Article

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