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Neuron. 2012 May 10;74(3):432-9. doi: 10.1016/j.neuron.2012.04.010.

A-to-I RNA editing: effects on proteins key to neural excitability.

Author information

1
Institute of Neurobiology and Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00901, USA.

Abstract

RNA editing by adenosine deamination is a process used to diversify the proteome. The expression of ADARs, the editing enzymes, is ubiquitous among true metazoans, and so adenosine deamination is thought to be universal. By changing codons at the level of mRNA, protein function can be altered, perhaps in response to physiological demand. Although the number of editing sites identified in recent years has been rising exponentially, their effects on protein function, in general, are less well understood. This review assesses the state of the field and highlights particular cases where the biophysical alterations and functional effects caused by RNA editing have been studied in detail.

PMID:
22578495
PMCID:
PMC3724421
DOI:
10.1016/j.neuron.2012.04.010
[Indexed for MEDLINE]
Free PMC Article

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