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J Infect Dis. 2012 Jun;205 Suppl 3:S391-8. doi: 10.1093/infdis/jis199.

Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies.

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1
Division of Endocrinology, Johns Hopkins University School of Medicine,1830 EMonument Street, Baltimore, MD 21287, USA.

Abstract

Osteoporosis is common in human immunodeficiency virus (HIV)-infected persons. The etiology of osteoporosis in HIV-infected patients is likely multifactorial, involving traditional risk factors such as low body weight, hypogonadism, and smoking, as well as direct effects of chronic HIV infection and antiretroviral therapy. Emerging evidence suggests that the increasing prevalence of osteoporosis in HIV-infected persons translates into a higher risk of fracture, likely leading to excess morbidity and mortality as the HIV-infected population ages. This review addresses the epidemiology of osteoporosis, discusses the causes of low bone mineral density in HIV-infected persons, including the impact of specific antiretroviral therapies, and offers recommendations on screening and treating vitamin D deficiency and osteoporosis.

PMID:
22577213
PMCID:
PMC3415950
DOI:
10.1093/infdis/jis199
[Indexed for MEDLINE]
Free PMC Article
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