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FEBS Lett. 2012 Jul 4;586(14):1897-905. doi: 10.1016/j.febslet.2012.02.001. Epub 2012 Feb 11.

Phosphatases in SMAD regulation.

Author information

1
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH Dundee, Scotland, UK.

Abstract

SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.

PMID:
22576046
DOI:
10.1016/j.febslet.2012.02.001
[Indexed for MEDLINE]
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