Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2012 Sep;1823(9):1617-32. doi: 10.1016/j.bbamcr.2012.04.009. Epub 2012 May 8.

One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.

Author information

1
Department of Animal & Avian Sciences, University of Maryland, College Park, MD 20742, USA. hamza@umd.edu

Abstract

The appearance of heme, an organic ring surrounding an iron atom, in evolution forever changed the efficiency with which organisms were able to generate energy, utilize gasses and catalyze numerous reactions. Because of this, heme has become a near ubiquitous compound among living organisms. In this review we have attempted to assess the current state of heme synthesis and trafficking with a goal of identifying crucial missing information, and propose hypotheses related to trafficking that may generate discussion and research. The possibilities of spatially organized supramolecular enzyme complexes and organelle structures that facilitate efficient heme synthesis and subsequent trafficking are discussed and evaluated. Recently identified players in heme transport and trafficking are reviewed and placed in an organismal context. Additionally, older, well established data are reexamined in light of more recent studies on cellular organization and data available from newer model organisms. This article is part of a Special Issue entitled: Cell Biology of Metals.

PMID:
22575458
PMCID:
PMC3412874
DOI:
10.1016/j.bbamcr.2012.04.009
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center