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Endocrinol Metab Clin North Am. 2012 Mar;41(1):175-201. doi: 10.1016/j.ecl.2012.01.001. Epub 2012 Feb 17.

Insulin therapy for the management of hyperglycemia in hospitalized patients.

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1
Department of Medicine, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA.

Abstract

It has long been established that hyperglycemia with or without a prior diagnosis of diabetes increases both mortality and disease-specific morbidity in hospitalized patients and that goal-directed insulin therapy can improve outcomes. This article reviews the pathophysiology of hyperglycemia during illness, the mechanisms for increased complications and mortality due to hyperglycemia and hypoglycemia, and beneficial mechanistic effects of insulin therapy and provides updated recommendations for the inpatient management of diabetes in the critical care setting and in the general medicine and surgical settings.

PMID:
22575413
PMCID:
PMC3738170
DOI:
10.1016/j.ecl.2012.01.001
[Indexed for MEDLINE]
Free PMC Article
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