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Endocrinol Metab Clin North Am. 2012 Mar;41(1):41-56. doi: 10.1016/j.ecl.2012.03.003. Epub 2012 Apr 5.

Reevaluating goals of insulin therapy: perspectives from large clinical trials.

Author information

1
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Mailcode L345, Portland, OR 97239, USA. riddlem@ohsu.edu

Abstract

Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.

PMID:
22575406
DOI:
10.1016/j.ecl.2012.03.003
[Indexed for MEDLINE]

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