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Endocrinol Metab Clin North Am. 2012 Mar;41(1):41-56. doi: 10.1016/j.ecl.2012.03.003. Epub 2012 Apr 5.

Reevaluating goals of insulin therapy: perspectives from large clinical trials.

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Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Mailcode L345, Portland, OR 97239, USA.


Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.

[Indexed for MEDLINE]

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