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Acta Obstet Gynecol Scand. 2012 Aug;91(8):970-5. doi: 10.1111/j.1600-0412.2012.01448.x. Epub 2012 Jun 27.

Age-related distributions of anti-Müllerian hormone level and anti-Müllerian hormone models.

Author information

1
Hamchoon Women's Clinic, Seoul, Korea.

Abstract

OBJECTIVE:

To determine age-specific reference values for anti-Müllerian hormone (AMH) and to set up an optimal model for AMH changes by age for infertility investigations.

DESIGN:

Prospective study.

SETTING:

Several infertility clinics and two university hospitals.

SAMPLE:

A total of 21 226 AMH samples were obtained.

METHODS:

Data on patients' age, race/ethnicity, and AMH levels were available from the laboratory center data registry between November 2008 and January 2011.

MAIN OUTCOME MEASURES:

The distribution of AMH levels by age. From 16 972 women aged between 25 and 45 years, we established and validated five AMH-age regression models.

RESULTS:

The overall mean AMH level was 4.09 ± 3.71 ng/mL (median: 3.13 ng/mL). There was an inverse relation between AMH level and age. Among multiple regression models, the quadratic model was most appropriate to describe AMH-age relation (log AMH = 0.205 × age - 0.005 × age(2) - 0.047).

CONCLUSIONS:

AMH levels show a progressive decline with increasing age. Age-specific AMH values may provide more specific information useful for patients and clinicians. AMH-age models could play a role as a basic step to approach more accurate ovarian reserve estimation.

[Indexed for MEDLINE]

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