Send to

Choose Destination
See comment in PubMed Commons below
Sensors (Basel). 2009;9(4):2538-54. doi: 10.3390/s90402538. Epub 2009 Apr 14.

Advances in microbial biofilm prevention on indwelling medical devices with emphasis on usage of acoustic energy.

Author information

Department of Cellular and Developmental Biology, Tel-Aviv University, Tel-Aviv, Israel; E-mail: (N.D).


Microbial biofilms are a major impediment to the use of indwelling medical devices, generating device-related infections with high morbidity and mortality. Major efforts directed towards preventing and eradicating the biofilm problem face difficulties because biofilms protect themselves very effectively by producing a polysaccharide coating, reducing biofilm sensitivity to antimicrobial agents. Techniques applied to combating biofilms have been primarily chemical. These have met with partial and limited success rates, leading to current trends of eradicating biofilms through physico-mechanical strategies. Here we review the different approaches that have been developed to control biofilm formation and removal, focusing on the utilization of acoustic energy to achieve these objectives.


Acoustic energy; Anti-microbial agents; Biofilm prevention; Biofilms; Ultrasonication

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
    Loading ...
    Support Center