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Angew Chem Int Ed Engl. 2012 May 21;51(21):5062-85. doi: 10.1002/anie.201107017. Epub 2012 May 9.

Palladium-catalyzed cross-coupling: a historical contextual perspective to the 2010 Nobel Prize.

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Johnson Matthey Catalysis & Chiral Technologies, Protech Building, Orchard Road, Royston, SG8 5HE UK.


In 2010, Richard Heck, Ei-ichi Negishi, and Akira Suzuki joined the prestigious circle of Nobel Laureate chemists for their roles in discovering and developing highly practical methodologies for C-C bond construction. From their original contributions in the early 1970s the landscape of the strategies and methods of organic synthesis irreversibly changed for the modern chemist, both in academia and in industry. In this Review, we attempt to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today.


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