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Gut Microbes. 2012 Jul-Aug;3(4):307-21. Epub 2012 May 10.

Gut-associated microbes of Drosophila melanogaster.

Author information

1
Global Health Institute, School of Life Science, EPFL, Station 19, Lausanne, Switzerland. nabroderick@gmail.com

Abstract

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that underlie the complex relationships between a host and its microbiota. In addition to the many genetic resources and tools Drosophila provides, its associated microbiota is relatively simple (1-30 taxa), in contrast to the complex diversity associated with vertebrates (> 500 taxa). These attributes highlight the potential of this system to dissect the complex cellular and molecular interactions that occur between a host and its microbiota. In this review, we summarize what is known regarding the composition of gut-associated microbes of Drosophila and their impact on host physiology. We also discuss these interactions in the context of their natural history and ecology and describe some recent insights into mechanisms by which Drosophila and its gut microbiota interact.

PMID:
22572876
PMCID:
PMC3463489
DOI:
10.4161/gmic.19896
[Indexed for MEDLINE]
Free PMC Article

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