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Indian Heart J. 2012 Mar-Apr;64(2):141-5. doi: 10.1016/S0019-4832(12)60049-2. Epub 2012 Apr 28.

Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.

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1
Frontier Lifeline Hospital, Chennai, Tamilnadu, India.

Abstract

AIMS AND OBJECTIVES:

Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS.

METHODS AND RESULTS:

Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874-0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive.

CONCLUSION:

Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.

PMID:
22572488
PMCID:
PMC3860616
DOI:
10.1016/S0019-4832(12)60049-2
[Indexed for MEDLINE]
Free PMC Article

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