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Curr Opin Struct Biol. 2012 Aug;22(4):520-8. doi: 10.1016/j.sbi.2012.04.003. Epub 2012 May 8.

Membrane protein structure determination by electron crystallography.

Author information

1
Department of Structural and Chemical Biology, Mt. Sinai School of Medicine, New York, NY 10029, United States.

Abstract

During the past year, electron crystallography of membrane proteins has provided structural insights into the mechanism of several different transporters and into their interactions with lipid molecules within the bilayer. From a technical perspective there have been important advances in high-throughput screening of crystallization trials and in automated imaging of membrane crystals with the electron microscope. There have also been key developments in software, and in molecular replacement and phase extension methods designed to facilitate the process of structure determination.

PMID:
22572457
PMCID:
PMC3423591
DOI:
10.1016/j.sbi.2012.04.003
[Indexed for MEDLINE]
Free PMC Article

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