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Neurosignals. 2013;21(3-4):259-71. doi: 10.1159/000337263. Epub 2012 May 9.

Neuronal functions of activators of G protein signaling.

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Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, SAR, China.


G protein-coupled receptors (GPCRs) are one of the most important gateways for signal transduction across the plasma membrane. Over the past decade, several classes of alternative regulators of G protein signaling have been identified and reported to activate the G proteins independent of the GPCRs. One group of such regulators is the activator of G protein signaling (AGS) family which comprises of AGS1-10. They have entirely different activation mechanisms for G proteins as compared to the classic model of GPCR-mediated signaling and confer upon cells new avenues of signal transduction. As GPCRs are widely expressed in our nervous system, it is believed that the AGS family plays a major role in modulating the G protein signaling in neurons. In this article, we will review the current knowledge on AGS proteins in relation to their potential roles in neuronal regulations.

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