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ACS Chem Biol. 2012 Jun 15;7(6):947-60. doi: 10.1021/cb3001793. Epub 2012 May 16.

Protein lysine acylation and cysteine succination by intermediates of energy metabolism.

Author information

1
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. hl379@cornell.edu

Abstract

In the past few years, several new protein post-translational modifications that use intermediates in metabolism have been discovered. These include various acyl lysine modifications (formylation, propionylation, butyrylation, crotonylation, malonylation, succinylation, myristoylation) and cysteine succination. Here, we review the discovery and the current understanding of these modifications. Several of these modifications are regulated by the deacylases, sirtuins, which use nicotinamide adenine dinucleotide (NAD), an important metabolic small molecule. Interestingly, several of these modifications in turn regulate the activity of metabolic enzymes. These new modifications reveal interesting connections between metabolism and protein post-translational modifications and raise many questions for future investigations.

PMID:
22571489
PMCID:
PMC3376250
DOI:
10.1021/cb3001793
[Indexed for MEDLINE]
Free PMC Article

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