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J Mol Med (Berl). 2012 Jul;90(7):783-90. doi: 10.1007/s00109-012-0908-x. Epub 2012 May 9.

Stem cells in ectodermal development.

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  • 1Centre for Genomic Regulation (CRG) and UPF, Dr. Aiguader 88 08003, Barcelona, Spain.

Abstract

Tissue-specific stem cells sustain organs for a lifetime through self-renewal and generating differentiated progeny. Although tissue stem cells are established during organogenesis, the precise origin of most adult stem cells in the developing embryo is unclear. Mammalian skin is one of the best-studied epithelial systems containing stem cells to date, however the origin of most of the stem cell populations found in the adult epidermis is unknown. Here, we try to recapitulate the emergence and genesis of an ectodermal stem cell during development until the formation of an adult skin. We ask whether skin stem cells share key transcriptional regulators with their embryonic counterparts and discuss whether embryonic-like stem cells may persist through to adulthood in vivo.

PMID:
22570240
PMCID:
PMC3383946
DOI:
10.1007/s00109-012-0908-x
[PubMed - indexed for MEDLINE]
Free PMC Article
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