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Microbes Infect. 2012 Aug;14(10):811-9. doi: 10.1016/j.micinf.2012.04.008. Epub 2012 May 5.

Insights into the Plasmodium falciparum schizont phospho-proteome.

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1
Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands. e.lasonder@ncmls.ru.nl

Abstract

It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

PMID:
22569589
DOI:
10.1016/j.micinf.2012.04.008
[Indexed for MEDLINE]
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