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FEBS Lett. 2012 Apr 5;586(7):1038-43. doi: 10.1016/j.febslet.2012.02.050. Epub 2012 Mar 8.

MicroRNA-223 regulates FOXO1 expression and cell proliferation.

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Department of Children's Health Care, Yu Ying Children's Hospital, Wenzhou Medical College, Wenzhou, PR China.

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  • FEBS Lett. 2013 Feb 14;587(4):387.


In HCT116 colorectal cancer cells, HeLa cervical cancer cells and HuH-7 hepatoma cells, miR-223 is expressed at a low level. Through infection with lentivirus containing miR-223 precursor, miR-223 [corrected] was overexpressed in all these cells. Interestingly, the expression levels of FOXO1 mRNA and protein, and phosphorylation levels became significantly lower than those of their control. FOXO1 was down-regulated mainly in the cytoplasm, while the nuclear FOXO1 level became relatively high compared to the cytoplasm. As the unphosphorylated active form of FOXO1 increased in the cells, cyclin D1/p21/p27 were up-regulated at either mRNA or protein level. Proliferation of the cells was also greatly inhibited when miR-223 was over-expressed. Therein, our data suggest that miR-223 regulates FOXO1 expression and cell proliferation.

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