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FEBS Lett. 2012 Apr 5;586(7):984-9. doi: 10.1016/j.febslet.2012.02.021. Epub 2012 Feb 22.

Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells.

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1
Laboratory of Experimental Medicine, Université Libre de Bruxelles, Brussels, Belgium. fernandaortis@hotmail.com

Abstract

The cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α induce β-cell death in type 1 diabetes via NF-κB activation. IL-1β induces a more marked NF-κB activation than TNF-α, with higher expression of genes involved in β-cell dysfunction and death. We show here a differential usage of the IKK complex by IL-1β and TNF-α in β-cells. While TNF-α uses IKK complexes containing both IKKα and IKKβ, IL-1β induces complexes with IKKα only; this effect is achieved by induction of IKKβ degradation via the proteasome. Both IKKγ and activation of the TRAF6-TAK1-JNK pathway are involved in IL-1β-induced IKKβ degradation.

PMID:
22569251
DOI:
10.1016/j.febslet.2012.02.021
[Indexed for MEDLINE]
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