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Soc Cogn Affect Neurosci. 2012 Jun;7(5):604-9. doi: 10.1093/scan/nss055. Epub 2012 May 7.

Tools of the trade: psychophysiological interactions and functional connectivity.

Author information

1
FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. joreilly@fmrib.ox.ac.uk

Abstract

Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to activity in a seed region of interest (seed ROI) in a given psychological context, such as during attention or in the presence of emotive stimuli. In this tutorial, we aim to give a simple conceptual explanation of how PPI analysis works, in order to assist readers in planning and interpreting their own PPI experiments.

PMID:
22569188
PMCID:
PMC3375893
DOI:
10.1093/scan/nss055
[Indexed for MEDLINE]
Free PMC Article

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