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Genet Res Int. 2011;2011:989303. doi: 10.4061/2011/989303. Epub 2011 Nov 22.

Genomic insights into the different layers of gene regulation in yeast.

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Departamento de Bioquímica y Biología Molecular, Facultad de Biológicas, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot, Spain.


The model organism Saccharomyces cerevisiae has allowed the development of new functional genomics techniques devoted to the study of transcription in all its stages. With these techniques, it has been possible to find interesting new mechanisms to control gene expression that act at different levels and for different gene sets apart from the known cis-trans regulation in the transcription initiation step. Here we discuss a method developed in our laboratory, Genomic Run-On, and other new methods that have recently appeared with distinct technical features. A comparison between the datasets generated by them provides interesting genomic insights into the different layers of gene regulation in eukaryotes.

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