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Artif DNA PNA XNA. 2011 Jul-Dec;2(3):69-70.

RNA-DNA sequence differences spell genetic code ambiguities.

Author information

1
Department of Cellular and Molecular Medicine, The Novo Nordisk Center for Protein Research, University of Copenhagen, Copenhagen, Denmark. bentin@sund.ku.dk

Abstract

A recent paper in Science by Li et al. 2011(1) reports widespread sequence differences in the human transcriptome between RNAs and their encoding genes termed RNA-DNA differences (RDDs). The findings could add a new layer of complexity to gene expression but the study has been criticized. 

KEYWORDS:

RNA editing; RNA-DNA differences; gene expression; transcription; transcriptome

PMID:
22567189
PMCID:
PMC3324336
[Indexed for MEDLINE]
Free PMC Article
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