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EMBO Rep. 2012 Jun 1;13(6):539-46. doi: 10.1038/embor.2012.54.

Age-related aneuploidy through cohesion exhaustion.

Author information

1
Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fiedlerstrasse 42, 01326 Dresden, Germany. rolf.jessberger@tu-dresden.de

Abstract

The trend of women to become pregnant when older than in previous generations poses a paramount medical problem, for oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Recent data strongly suggest that as oocyte age increases sister chromatid cohesion is weakened or lost. Cohesin deterioration seems to contribute significantly to age-dependent aneuploidy, as discussed in this review.

PMID:
22565322
PMCID:
PMC3367239
DOI:
10.1038/embor.2012.54
[Indexed for MEDLINE]
Free PMC Article
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