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Curr Atheroscler Rep. 2012 Aug;14(4):343-50. doi: 10.1007/s11883-012-0254-z.

The pathophysiology and clinical presentation of cerebral amyloid angiopathy.

Author information

1
J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA.

Abstract

Cerebral amyloid angiopathy (CAA) is defined as the deposition of amyloid ß peptide within leptomeningial and cortical vessels, likely reflecting an imbalance between Aβ production and clearance. Amyloid buildup triggers a series of destructive alterations in the cerebral vascular architecture, leading to a spectrum of neurological events including lobar intracerebral hemorrhage, brain ischemia and cognitive decline. Although traditionally diagnosed pathologically, neuroimaging has taken a central role in defining CAA. This review will discuss the pathological, clinical and radiological aspects of CAA.

PMID:
22565298
DOI:
10.1007/s11883-012-0254-z
[Indexed for MEDLINE]

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