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Epidemiol Infect. 2013 Feb;141(2):344-52. doi: 10.1017/S0950268812000763. Epub 2012 May 8.

Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England.

Author information

1
Health Protection Agency North East, North East Regional Epidemiology Unit, Gallowgate, Newcastle upon Tyne, UK.
2
Health Protection Agency North East, North East Health Protection Unit, Gallowgate, Newcastle upon Tyne, UK.

Abstract

The 7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine childhood immunization programme in the UK since September 2006. A population-based study of serotypes causing invasive pneumococcal disease (IPD) post-PCV7 in North East England was conducted using data from a regional enhanced IPD surveillance system. Overall, there was a 20% reduction [95% confidence interval (CI) 5-32] from 12·1 cases/100 000 population in 2006/2007 to 9·7 in 2009/2010. There was a fall in IPD caused by PCV7 serotypes in all age groups, with reductions of 90% (95% CI 61-99) in children aged <5 years, 50% (95% CI 4-75) in persons aged 5-64 years and 66% (95% CI 40-82) in adults aged ⩾65 years. There was a non-significant increase in IPD caused by non-PCV7 serotypes in children aged <5 years of 88% (95% CI -10 to 312) and adults aged ⩾65 years of 12% (95% CI -19 to 50), which was largely caused by serotypes 7F, 19A and 22F. Replacement disease appears to have reduced the benefits of PCV7 in North East England.

PMID:
22564258
DOI:
10.1017/S0950268812000763
[Indexed for MEDLINE]

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