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Epidemiol Infect. 2013 Feb;141(2):344-52. doi: 10.1017/S0950268812000763. Epub 2012 May 8.

Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England.

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Health Protection Agency North East, North East Regional Epidemiology Unit, Gallowgate, Newcastle upon Tyne, UK.
Health Protection Agency North East, North East Health Protection Unit, Gallowgate, Newcastle upon Tyne, UK.


The 7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine childhood immunization programme in the UK since September 2006. A population-based study of serotypes causing invasive pneumococcal disease (IPD) post-PCV7 in North East England was conducted using data from a regional enhanced IPD surveillance system. Overall, there was a 20% reduction [95% confidence interval (CI) 5-32] from 12·1 cases/100 000 population in 2006/2007 to 9·7 in 2009/2010. There was a fall in IPD caused by PCV7 serotypes in all age groups, with reductions of 90% (95% CI 61-99) in children aged <5 years, 50% (95% CI 4-75) in persons aged 5-64 years and 66% (95% CI 40-82) in adults aged ⩾65 years. There was a non-significant increase in IPD caused by non-PCV7 serotypes in children aged <5 years of 88% (95% CI -10 to 312) and adults aged ⩾65 years of 12% (95% CI -19 to 50), which was largely caused by serotypes 7F, 19A and 22F. Replacement disease appears to have reduced the benefits of PCV7 in North East England.

[Indexed for MEDLINE]

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