Format

Send to

Choose Destination
J Neuroendocrinol. 2012 Sep;24(9):1183-200. doi: 10.1111/j.1365-2826.2012.02335.x.

Dependence of the excitability of pituitary cells on cyclic nucleotides.

Author information

1
Sections on Cellular Signalling and Endocrinology and Genetics, The Eunice Kennedy Shiver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Abstract

Cyclic 3',5'-adenosine monophosphate and cyclic 3',5'-guanosine monophosphate are intracellular (second) messengers that are produced from the nucleotide triphosphates by a family of enzymes consisting of adenylyl and guanylyl cyclases. These enzymes are involved in a broad array of signal transduction pathways mediated by the cyclic nucleotide monophosphates and their kinases, which control multiple aspects of cell function through the phosphorylation of protein substrates. We review the findings and working hypotheses on the role of the cyclic nucleotides and their kinases in the control of electrical activity of the endocrine pituitary cells and the plasma membrane channels involved in this process.

PMID:
22564128
PMCID:
PMC3421050
DOI:
10.1111/j.1365-2826.2012.02335.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center