Format

Send to

Choose Destination
Soc Cogn Affect Neurosci. 2013 Aug;8(6):711-9. doi: 10.1093/scan/nss049. Epub 2012 May 3.

Early and late motor responses to action observation.

Author information

1
Center for Mind/Brain Sciences (CIMeC), University of Trento, Via delle Regole, 101, I-38123 Mattarello (TN), Italy.

Abstract

Is a short visuomotor associative training sufficient to reverse the visuomotor tuning of mirror neurons in adult humans? We tested the effects of associative training on corticospinal modulation during action observation in the 100-320 ms interval after action onset. In two separate experiments, the acceleration of transcranial magnetic stimulation (TMS)-induced movements was recorded before and after training participants to respond to observed acts with an opposite or similar behavior. Before training, TMS-induced accelerations mirrored the observed action at 250 and 320 ms. After training, responses at 250 ms were unchanged and still mirrored the stimuli, without any effect of training direction. Only at 320 ms, we observed training-dependent changes in evoked responses. A control experiment with non-biological rotational movements as visual stimuli indicated that spatial stimulus-response compatibility is not sufficient to account for the results of the two main experiments. We show that the effects of a short visuomotor associative training are not pervasive on the automatic mirror responses. 'Early' (250 ms) responses were not influenced by training. Conversely only 'late' (320 ms) responses changed according to the training direction. This biphasic time course indicates that two distinct mechanisms produce the automatic mirror responses and the newly learned visuomotor associations.

KEYWORDS:

action observation; action selection; associative sequence learning; mirror neurons; transcranial magnetic stimulation; visual motor training

PMID:
22563004
PMCID:
PMC3739914
DOI:
10.1093/scan/nss049
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center