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Nat Med. 2012 May 4;18(5):660-1. doi: 10.1038/nm.2762.

King of hearts: a splicing factor rules cardiac proteins.

Author information

1
Department of Cardiovascular Physiology, Ruhr University Bochum, Germany. wolfgang.linke@rub.de

Abstract

Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).

PMID:
22561820
DOI:
10.1038/nm.2762
[Indexed for MEDLINE]

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