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Cancer Lett. 2012 Sep 28;322(2):148-58. doi: 10.1016/j.canlet.2012.02.038. Epub 2012 May 2.

MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5.

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Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, China.


MicroRNAs (miRNAs) play a key role in the regulation of gene expression. In this study, we demonstrate that microRNA-19a and -19b (miR-19a/b) are highly expressed in human cervical cancer cells and are involved in maintaining the malignant phenotypes of HeLa and C33A cells. Up-regulation of miR-19a and miR-19b promoted cell growth and invasion, whereas knockdown of miR-19a and miR-19b yielded the reverse phenotype. CUL5 was identified as a novel target gene of both miR-19a and miR-19b. CUL5 ectopic over-expression without its 3' untranslated region (UTR) abolished the effect of miR-19a/b on HeLa and C33A cell proliferation and invasion. These results indicated that miR-19a/b directly and negatively regulate CUL5 expression in cervical cancer cells, highlighting the importance of miR-19a and miR-19b and their target genes in tumorigenesis.

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