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Eur J Med Chem. 2012 Jul;53:246-53. doi: 10.1016/j.ejmech.2012.04.006. Epub 2012 Apr 14.

Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives.

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1
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Ple A Moro 5, 00185 Rome, Italy.

Abstract

Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.

PMID:
22560629
DOI:
10.1016/j.ejmech.2012.04.006
[Indexed for MEDLINE]

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