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Curr Opin Immunol. 2012 Aug;24(4):482-7. doi: 10.1016/j.coi.2012.04.005. Epub 2012 May 5.

Homeostasis and function of regulatory T cells in aging.

Author information

1
Division of Cellular and Molecular Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA.

Abstract

A hallmark of aging is the progressive deterioration of immune function. Age-related immune suppression increases susceptibility to infectious diseases and cancer, significant causes of morbidity and mortality in the elderly. In particular, age-related T cell dysfunction is a major contributor to 'immune-senescence'. Recently, it has become clear that the frequency of regulatory T cells (Treg) significantly increases in aged mice and humans. As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging.

PMID:
22560294
PMCID:
PMC3419320
DOI:
10.1016/j.coi.2012.04.005
[Indexed for MEDLINE]
Free PMC Article

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