Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Metab. 2012 May 2;15(5):635-45. doi: 10.1016/j.cmet.2012.04.001.

Inflammation and lipid signaling in the etiology of insulin resistance.

Author information

1
Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0673, USA. ckg@ucsd.edu

Abstract

Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies indicate that many other lipid species act to positively and negatively regulate inflammatory responses. Conversely, inflammatory signaling can significantly alter lipid metabolism in the liver, adipose tissue, skeletal muscle, and macrophage in the context of infection, diabetes, and atherosclerosis. Here, we review recent findings related to this interconnected network from the perspective of immunity and metabolic disease.

PMID:
22560216
PMCID:
PMC4156155
DOI:
10.1016/j.cmet.2012.04.001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center