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Cell Metab. 2012 May 2;15(5):606-14. doi: 10.1016/j.cmet.2012.01.024.

Interplay between lipids and branched-chain amino acids in development of insulin resistance.

Author information

1
Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology, Duke University Medical Center, Durham, NC 27704, USA. chris.newgard@duke.edu

Abstract

Fatty acids (FA) and FA-derived metabolites have long been implicated in the development of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics technologies has revealed that branched-chain amino acids (BCAA) and related metabolites are more strongly associated with insulin resistance than many common lipid species. Moreover, the BCAA-related signature is predictive of incident diabetes and intervention outcomes and uniquely responsive to therapeutic interventions. Nevertheless, in animal feeding studies, BCAA supplementation requires the background of a high-fat diet to promote insulin resistance. This Perspective develops a model to explain how lipids and BCAA may synergize to promote metabolic diseases.

PMID:
22560213
PMCID:
PMC3695706
DOI:
10.1016/j.cmet.2012.01.024
[Indexed for MEDLINE]
Free PMC Article
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