Format

Send to

Choose Destination
Cell Metab. 2012 May 2;15(5):595-605. doi: 10.1016/j.cmet.2012.04.010.

Lipid-induced mitochondrial stress and insulin action in muscle.

Author information

1
Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA. muoio@duke.edu

Abstract

The interplay between mitochondrial energetics, lipid balance, and muscle insulin sensitivity has remained a topic of intense interest and debate for decades. One popular view suggests that increased oxidative capacity benefits metabolic wellness, based on the premise that it is healthier to burn fat than glucose. Attempts to test this hypothesis using genetically modified mouse models have produced contradictory results and instead link muscle insulin resistance to excessive fat oxidation, acylcarnitine production, and increased mitochondrial H(2)O(2)-emitting potential. Here, we consider emerging evidence that insulin action in muscle is driven principally by mitochondrial load and redox signaling rather than oxidative capacity.

PMID:
22560212
PMCID:
PMC3348508
DOI:
10.1016/j.cmet.2012.04.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center