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Cell Metab. 2012 May 2;15(5):570-3. doi: 10.1016/j.cmet.2012.03.004.

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.

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1
Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA. bfarese@gladstone.ucsf.edu

Abstract

Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by hepatic insulin resistance. Whether this correlation is due to a causal relationship between the conditions has been the subject of considerable debate, and the literature abounds with conflicting data and theories. Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions.

PMID:
22560209
PMCID:
PMC3767424
DOI:
10.1016/j.cmet.2012.03.004
[Indexed for MEDLINE]
Free PMC Article
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