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Cell Metab. 2012 May 2;15(5):567-9. doi: 10.1016/j.cmet.2012.04.015.

Muscling in on PGC-1α for improved quality of life in ALS.

Author information

1
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA. johri.ashu@gmail.com

Abstract

Impaired activity of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis.

PMID:
22560208
DOI:
10.1016/j.cmet.2012.04.015
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