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Cell Stem Cell. 2012 May 4;10(5):504-14. doi: 10.1016/j.stem.2012.04.001.

Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.

Author information

1
Center of Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. abrack@partners.org

Abstract

In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle fiber and the basement membrane. In recent years it has been conclusively demonstrated that the satellite cell is the primary cellular source for muscle regeneration and is equipped with the potential to self renew, thus functioning as a bona fide skeletal muscle stem cell (MuSC). As we move past the 50(th) anniversary of the satellite cell, we take this opportunity to discuss the current state of the art and dissect the unknowns in the MuSC field.

PMID:
22560074
PMCID:
PMC3348769
DOI:
10.1016/j.stem.2012.04.001
[Indexed for MEDLINE]
Free PMC Article

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